Thrombotic disorders may be characterized by a single major thrombus, frequently observed in acute ischemic stroke, in large vessels, or numerous thrombi throughout the body, as is seen in Thrombotic Thrombocytopenic Purpura (TTP) and Disseminated Intravascular Coagulation. Widespread microvascular thrombosis can lead to ischemia (tissue damage or death due to decreased blood supply) in multiple organs, ultimately resulting in organ failure. Also a major macrovascular thrombus will lead to impaired blood supply to the vessels immediately downstream of the occluding blood clot and cause tissue damage. Tissue damage is often irreversible and may lead to life-long disabilities.
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